Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance

Toll-like receptors 7 and 8 (TLR7 and TLR8) are endosomal pattern recognition receptors that detect a variety of single-stranded RNA species. While TLR7/8 agonists have robust therapeutic potential, clinical utility of these agents is limited by sickness responses associated with treatment induction...

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Pubblicato in:Brain Behav Immun
Autori principali: Michaelis, Katherine A., Norgard, Mason A., Levasseur, Peter R., Olson, Brennan, Burfeind, Kevin G., Buenafe, Abigail C., Zhu, Xinxia, Jeng, Sophia, McWeeney, Shannon K., Marks, Daniel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956569/
https://ncbi.nlm.nih.gov/pubmed/31499172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2019.09.004
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