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Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line

Background and Objectives: Acute lymphoblastic leukemia (ALL) is the most common type of cancer in childhood. The majority of patients respond to treatment, but those with resistant phenotypes suffer relapse or death. The antifolate methotrexate (MTX) is the most commonly used drug against ALL due t...

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Bibliografski detalji
Izdano u:Medicina (Kaunas)
Glavni autori: Mendoza-Santiago, Alma, Becerra, Edgardo, Garay, Edith, Bah, Moustapha, Berumen-Segura, Laura, Escobar-Cabrera, Jesica, Hernández-Pérez, Abigail, García-Alcocer, Guadalupe
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956105/
https://ncbi.nlm.nih.gov/pubmed/31779260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/medicina55120758
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