Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques

Hsp90 plays a central role in cell homeostasis by assisting folding and maturation of a large variety of clients. It is a homo-dimer, which functions via hydrolysis of ATP-coupled to conformational changes. Hsp90’s conformational cycle in the absence of cochaperones is currently postulated as apo-Hs...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Giannoulis, Angeliki, Feintuch, Akiva, Barak, Yoav, Mazal, Hisham, Albeck, Shira, Unger, Tamar, Yang, Feng, Su, Xun-Cheng, Goldfarb, Daniella
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955315/
https://ncbi.nlm.nih.gov/pubmed/31862713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916030116
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