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The Catalytic Mn(2+) Sites in the Enolase-Inhibitor Complex - Crystallography, Single Crystal EPR and DFT Calculations

Crystals of Zn(2+) / Mn(2+) yeast enolase with the inhibitor PhAH (phosphonoacetohydroxamate) were grown under conditions with a slight preference for binding of Zn(2+) at the higher affinity site, site I. The structure of the Zn(2+)/Mn(2+) PhAH complex was solved at a resolution of 1.54 Å and the t...

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Detalhes bibliográficos
Main Authors: Carmieli, Raanan, Larsen, Todd M., Reed, George H., Zein, Samir, Neese, Frank, Goldfarb, Daniella
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538446/
https://ncbi.nlm.nih.gov/pubmed/17367133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja066124e
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