Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization

The Spinal Muscular Atrophy (SMA) gene SMN was recently duplicated (SMN1 and SMN2) in higher primates. Furthermore, invasion of the locus by repetitive elements almost doubled its size with respect to mouse Smn, in spite of an almost identical protein-coding sequence. Herein, we found that SMN ranks...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Pagliarini, Vittoria, Jolly, Ariane, Bielli, Pamela, Di Rosa, Valentina, De la Grange, Pierre, Sette, Claudio
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954450/
https://ncbi.nlm.nih.gov/pubmed/31777926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1117
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