MEK/MELK inhibition and blood–brain barrier deficiencies in atypical teratoid/rhabdoid tumors

BACKGROUND: Atypical teratoid/rhabdoid tumors (AT/RT) are rare, but highly aggressive. These entities are of embryonal origin occurring in the central nervous system (CNS) of young children. Molecularly these tumors are driven by a single hallmark mutation, resulting in inactivation of SMARCB1 or SM...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Meel, Michaël H, Guillén Navarro, Miriam, de Gooijer, Mark C, Metselaar, Dennis S, Waranecki, Piotr, Breur, Marjolein, Lagerweij, Tonny, Wedekind, Laurine E, Koster, Jan, van de Wetering, Marianne D, Schouten-van Meeteren, Netteke, Aronica, Eleonora, van Tellingen, Olaf, Bugiani, Marianna, Phoenix, Timothy N, Kaspers, Gertjan J L, Hulleman, Esther
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954444/
https://ncbi.nlm.nih.gov/pubmed/31504799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz151
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