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Efficient dose-finding for drug combination studies involving a shift in study populations

This paper describes the design of an early phase, prospective trial evaluating the safety and tolerability of the combination of the histone deacetylase inhibitor, entinostat, in combination with capecitabine. The study consists of two parts; an initial phase evaluating the safety of the combinatio...

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Podrobná bibliografie
Vydáno v:Contemp Clin Trials Commun
Hlavní autoři: Wages, Nolan A., Millard, Trish A., Dillon, Patrick M., Brenin, Christiana M., Petroni, Gina R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953647/
https://ncbi.nlm.nih.gov/pubmed/31938755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conctc.2020.100519
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