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Efficient dose-finding for drug combination studies involving a shift in study populations

This paper describes the design of an early phase, prospective trial evaluating the safety and tolerability of the combination of the histone deacetylase inhibitor, entinostat, in combination with capecitabine. The study consists of two parts; an initial phase evaluating the safety of the combinatio...

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Detalhes bibliográficos
Publicado no:Contemp Clin Trials Commun
Main Authors: Wages, Nolan A., Millard, Trish A., Dillon, Patrick M., Brenin, Christiana M., Petroni, Gina R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953647/
https://ncbi.nlm.nih.gov/pubmed/31938755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conctc.2020.100519
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