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A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies

Little is known about the relative performance of competing model-based dose-finding methods for combination phase I trials. In this study, we focused on five model-based dose-finding methods that have been recently developed. We compared the recommendation rates for true maximum-tolerated dose comb...

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Vydáno v:Stat Med
Hlavní autoři: Hirakawa, Akihiro, Wages, Nolan A., Sato, Hiroyuki, Matsui, Shigeyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806394/
https://ncbi.nlm.nih.gov/pubmed/25974405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6533
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