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Nascent polypeptide domain topology and elongation rate direct the cotranslational hierarchy of Hsp70 and TRiC/CCT

Cotranslational protein folding requires assistance from elaborate ribosome-associated chaperone networks. It remains unclear how the changing information in a growing nascent polypeptide dictates the recruitment of functionally distinct chaperones. Here, we used ribosome profiling to define the pri...

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Foilsithe in:Mol Cell
Main Authors: Stein, Kevin C., Kriel, Allison, Frydman, Judith
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953483/
https://ncbi.nlm.nih.gov/pubmed/31400849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.036
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