טוען...
GCN2 is essential for CD8(+) T cell survival and function in murine models of malignant glioma
Amino acid deprivation is a strategy that malignancies utilize to blunt anti-tumor T-cell immune responses. It has been proposed that amino acid insufficiency in T-cells is detected by GCN2 kinase, which through phosphorylation of EIF2α, shuts down global protein synthesis leading to T-cell arrest....
שמור ב:
| הוצא לאור ב: | Cancer Immunol Immunother |
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| Main Authors: | , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Springer Berlin Heidelberg
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6952559/ https://ncbi.nlm.nih.gov/pubmed/31844909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-019-02441-6 |
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