GCN2 is essential for CD8(+) T cell survival and function in murine models of malignant glioma

Amino acid deprivation is a strategy that malignancies utilize to blunt anti-tumor T-cell immune responses. It has been proposed that amino acid insufficiency in T-cells is detected by GCN2 kinase, which through phosphorylation of EIF2α, shuts down global protein synthesis leading to T-cell arrest....

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Immunother
Main Authors: Rashidi, Aida, Miska, Jason, Lee-Chang, Catalina, Kanojia, Deepak, Panek, Wojciech K., Lopez-Rosas, Aurora, Zhang, Peng, Han, Yu, Xiao, Ting, Pituch, Katarzyna C., Kim, Julius W., Talebian, Mahsa, Fares, Jawad, Lesniak, Maciej S.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952559/
https://ncbi.nlm.nih.gov/pubmed/31844909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-019-02441-6
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