Ładuje się......
GCN2 is essential for CD8(+) T cell survival and function in murine models of malignant glioma
Amino acid deprivation is a strategy that malignancies utilize to blunt anti-tumor T-cell immune responses. It has been proposed that amino acid insufficiency in T-cells is detected by GCN2 kinase, which through phosphorylation of EIF2α, shuts down global protein synthesis leading to T-cell arrest....
Zapisane w:
| Wydane w: | Cancer Immunol Immunother |
|---|---|
| Główni autorzy: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Springer Berlin Heidelberg
2019
|
| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6952559/ https://ncbi.nlm.nih.gov/pubmed/31844909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-019-02441-6 |
| Etykiety: |
Dodaj etykietę
Nie ma etykietki, Dołącz pierwszą etykiete!
|