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IMMU-06. GCN2 KINASE IS ESSENTIAL FOR ADAPTIVE T-CELL IMMUNITY IN GLIOMA
GCN2 Kinase is a stress sensing enzyme that is activated upon amino acid depletion, shutting down global gene expression as a means of energy conservation. This gene has been implicated as the mechanistic explanation for how tryptophan depletion by indolamine 2-3-dioxygenase (IDO1) induces immunosup...
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Publicado no: | Neuro Oncol |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692749/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.465 |
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