IMMU-06. GCN2 KINASE IS ESSENTIAL FOR ADAPTIVE T-CELL IMMUNITY IN GLIOMA

GCN2 Kinase is a stress sensing enzyme that is activated upon amino acid depletion, shutting down global gene expression as a means of energy conservation. This gene has been implicated as the mechanistic explanation for how tryptophan depletion by indolamine 2-3-dioxygenase (IDO1) induces immunosup...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Rashidi, Aida, Miska, Jason, Pituch, Katarzyna, Kanojia, Deepak, Lopez-Rosas, Aurora, Han, Yu, Kim, Julius W, Panek, Wojciech K, Muroski, Megan, Lesniak, Maciej S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692749/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.465
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