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IMMU-06. ABSENCE OF THE AMINO ACID STRESS-SENSOR GCN2 REDUCES SUPPRESSIVE EFFECTS OF MDSCs IN GLIOMA
Regulation of nutrient availability is a critical way by which tumors exert their immunosuppressive effects on the host. The glioblastoma microenvironment, in particular, is enriched in expression of indoleamine 2,3- dioxygenase 1 (IDO1), which depletes tryptophan from the microenvironment. Upon dep...
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| Publicat a: | Neuro Oncol |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217338/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.509 |
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