IMMU-06. ABSENCE OF THE AMINO ACID STRESS-SENSOR GCN2 REDUCES SUPPRESSIVE EFFECTS OF MDSCs IN GLIOMA

Regulation of nutrient availability is a critical way by which tumors exert their immunosuppressive effects on the host. The glioblastoma microenvironment, in particular, is enriched in expression of indoleamine 2,3- dioxygenase 1 (IDO1), which depletes tryptophan from the microenvironment. Upon dep...

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Publicado en:Neuro Oncol
Main Authors: Rashidi, Aida, Miska, Jason, Lee-Chang, Catalina, Kanojia, Deepak, Panek, Wojciech, Lopez-Rosas, Aurora, Han, Yu, Kim, Julius, Pituch, Katarzyna, Lesniak, Maciej
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217338/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.509
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