DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes

In C. elegans, the conserved transcription factor DAF-16/FOXO is a powerful aging regulator, relaying dire conditions into expression of stress resistance and longevity promoting genes. For some of these functions, including low insulin/IGF signaling (IIS), DAF-16 depends on the protein SMK-1/SMEK,...

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Udgivet i:Nat Commun
Main Authors: Sen, Ilke, Zhou, Xin, Chernobrovkin, Alexey, Puerta-Cavanzo, Nataly, Kanno, Takaharu, Salignon, Jérôme, Stoehr, Andrea, Lin, Xin-Xuan, Baskaner, Bora, Brandenburg, Simone, Björkegren, Camilla, Zubarev, Roman A., Riedel, Christian G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952425/
https://ncbi.nlm.nih.gov/pubmed/31919361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13931-7
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