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DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function
The FOXO transcription factor family is a conserved regulator of longevity and the downstream target of insulin/insulin-like signaling. In Caenorhabditis elegans, the FOXO ortholog DAF-16A and D/F isoforms extend lifespan in daf-2 insulin-like receptor mutants. Here we identify the DAF-21/Hsp90 chap...
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| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6089956/ https://ncbi.nlm.nih.gov/pubmed/30104664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30592-6 |
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