The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO

The conserved DAF-16/FOXO transcription factors and SIR-2.1/SIRT1 deacetylases are critical for diverse biological processes, particularly longevity and stress response; and complex regulation of DAF-16/FOXO by SIR-2.1/SIRT1 is central to appropriate biological outcomes. Caenorhabditis elegans Host...

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Detalhes bibliográficos
Main Authors: Rizki, Gizem, Iwata, Terri Naoko, Li, Ji, Riedel, Christian G., Picard, Colette Lafontaine, Jan, Max, Murphy, Coleen T., Lee, Siu Sylvia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164695/
https://ncbi.nlm.nih.gov/pubmed/21909281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002235
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