MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1. W...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Sdelci, Sara, Rendeiro, André F., Rathert, Philipp, You, Wanhui, Lin, Jung-Ming G., Ringler, Anna, Hofstätter, Gerald, Moll, Herwig P., Gürtl, Bettina, Farlik, Matthias, Schick, Sandra, Klepsch, Freya, Oldach, Matthew, Buphamalai, Pisanu, Schischlik, Fiorella, Májek, Peter, Parapatics, Katja, Schmidl, Christian, Schuster, Michael, Penz, Thomas, Buckley, Dennis L., Hudecz, Otto, Imre, Richard, Wang, Shuang-Yan, Maric, Hans Michael, Kralovics, Robert, Bennett, Keiryn L., Müller, Andre C., Mechtler, Karl, Menche, Jörg, Bradner, James E., Winter, Georg E., Klavins, Kristaps, Casanova, Emilio, Bock, Christoph, Zuber, Johannes, Kubicek, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952269/
https://ncbi.nlm.nih.gov/pubmed/31133746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0413-z
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