Systematic characterization of BAF mutations provides insights into intra-complex synthetic lethalities in human cancers

Aberrations in genes coding for subunits of the BAF chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not understood how these loss-of-function mutations contribute to cancer development and how they can be targeted therapeutically. The cancer-type-specific occurr...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Genet
Main Authors: Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Mueller, André C., Bock, Christoph, Kubicek, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952272/
https://ncbi.nlm.nih.gov/pubmed/31427792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0477-9
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker