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Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers
The taccalonolides are a class of microtubule stabilizers that circumvent clinically relevant forms of drug resistance due to their unique mechanism of microtubule stabilization imparted by the covalent binding of the C-22−–-23 epoxide moiety to tubulin. A taccalonolide (8) with a fluorescein group...
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| Publicado en: | J Nat Prod |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6952213/ https://ncbi.nlm.nih.gov/pubmed/30799622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.8b01036 |
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