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Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

The taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome clinically relevant taxane resistance mechanisms. Evaluations of the target specificity and detailed drug–target interactions of taccalonolides, however, have been limited in part by their irreversible target engagement...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Du, Lin, Yee, Samantha S., Ramachandran, Karthik, Risinger, April L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994698/
https://ncbi.nlm.nih.gov/pubmed/32005831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14277-w
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