Loading...
Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
The taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome clinically relevant taxane resistance mechanisms. Evaluations of the target specificity and detailed drug–target interactions of taccalonolides, however, have been limited in part by their irreversible target engagement...
Na minha lista:
| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6994698/ https://ncbi.nlm.nih.gov/pubmed/32005831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14277-w |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|