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Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
The taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome clinically relevant taxane resistance mechanisms. Evaluations of the target specificity and detailed drug–target interactions of taccalonolides, however, have been limited in part by their irreversible target engagement...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6994698/ https://ncbi.nlm.nih.gov/pubmed/32005831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14277-w |
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