Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

This review focuses on mechanisms of calorie restriction (CR), particularly the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis as an evolutionary conserved signal that regulates aging and lifespan, underlying the effects of CR in mammals. Topics include (1) the relation of the GH-IGF-...

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Detalhes bibliográficos
Publicado no:Nutrients
Main Authors: Komatsu, Toshimitsu, Park, Seongjoon, Hayashi, Hiroko, Mori, Ryoichi, Yamaza, Haruyoshi, Shimokawa, Isao
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950657/
https://ncbi.nlm.nih.gov/pubmed/31888201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu11123068
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