The life-extending effect of dietary restriction requires Foxo3 in mice

Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous ((+/–)) and homozygous ((–/–)) mice were subje...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Shimokawa, Isao, Komatsu, Toshimitsu, Hayashi, Nobutaka, Kim, Sang-Eun, Kawata, Takuya, Park, Seongjoon, Hayashi, Hiroko, Yamaza, Haruyoshi, Chiba, Takuya, Mori, Ryoichi
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531086/
https://ncbi.nlm.nih.gov/pubmed/25808402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12340
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