Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24‐hydroxylase (CYP46A1), a brain‐specific enzyme responsible for the elimination of cholesterol through the co...

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Veröffentlicht in:EMBO Mol Med
Hauptverfasser: Han, Mingzhi, Wang, Shuai, Yang, Ning, Wang, Xu, Zhao, Wenbo, Saed, Halala Sdik, Daubon, Thomas, Huang, Bin, Chen, Anjing, Li, Gang, Miletic, Hrvoje, Thorsen, Frits, Bjerkvig, Rolf, Li, Xingang, Wang, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949512/
https://ncbi.nlm.nih.gov/pubmed/31777202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910924
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