Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis

Natural product biosynthetic pathways are replete with enzymes repurposed for new catalytic functions. In some modular polyketide synthase (PKS) pathways, a GCN5-related N-acetyltransferase (GNAT)-like enzyme with an additional decarboxylation function initiates biosynthesis. Here, we probe two PKS...

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Udgivet i:Structure
Main Authors: Skiba, Meredith A., Tran, Collin L., Dan, Qingyun, Sikkema, Andrew P., Klaver, Zachary, Gerwick, William H., Sherman, David H., Smith, Janet L.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949403/
https://ncbi.nlm.nih.gov/pubmed/31785925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.11.004
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