High frequency of shared clonotypes in human B cell receptor repertoires

The human genome contains approximately 20 thousand protein-coding genes(1), but the size of the collection of adaptive immune system antigen receptors generated by recombination of gene segments with non-templated junctional additions (on B cells) is orders of magnitude larger and unknown. It is no...

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Veröffentlicht in:Nature
Hauptverfasser: Soto, Cinque, Bombardi, Robin G., Branchizio, Andre, Kose, Nurgun, Matta, Pranathi, Sevy, Alexander M., Sinkovits, Robert S., Gilchuk, Pavlo, Finn, Jessica A., Crowe, James E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949180/
https://ncbi.nlm.nih.gov/pubmed/30760926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0934-8
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