Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

Despite the availability of highly effective direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) infections, sustained viral response (SVR) rates remain suboptimal for difficult-to-treat patient populations such as those with HCV genotype 3, cirrhosis or prior treatme...

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Bibliographic Details
Published in:PLoS One
Main Authors: Good, Steven S., Moussa, Adel, Zhou, Xiao-Jian, Pietropaolo, Keith, Sommadossi, Jean-Pierre
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949113/
https://ncbi.nlm.nih.gov/pubmed/31914458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227104
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