Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity

Inherited retinal degenerations originate from mutations in >300 genes, many of which cause the production of misfolded mutant photoreceptor proteins that are ultimately degraded by the ubiquitin-proteasome system (UPS). It was previously shown that rod photoreceptors in multiple mouse models of...

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Udgivet i:eNeuro
Main Authors: Dexter, Paige M., Lobanova, Ekaterina S., Finkelstein, Stella, Arshavsky, Vadim Y.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2020
Fag:
New Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948925/
https://ncbi.nlm.nih.gov/pubmed/31826915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0428-19.2019
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