Role of HLA-B Exon 1 in Graft-versus-Host Disease After Unrelated Donor Transplantation: A Retrospective Cohort Study

BACKGROUND: The success of unrelated hematopoietic-cell transplantation (HCT) is limited by graft-versus-host disease (GVHD). A sequence dimorphism in exon one of HLA-B gives rise to leader peptides containing methionine (M) or threonine (T) which differentially influence NK and T-cell alloresponses...

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Publicat a:Lancet Haematol
Autors principals: Petersdorf, Effie W., Carrington, Mary, O’hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J. Alejandro, Maiers, Martin J., Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen R., Villard, Jean, Stevenson, Phil
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948919/
https://ncbi.nlm.nih.gov/pubmed/31669248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2352-3026(19)30208-X
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