Role of HLA-B Exon 1 in Graft-versus-Host Disease After Unrelated Donor Transplantation: A Retrospective Cohort Study

BACKGROUND: The success of unrelated hematopoietic-cell transplantation (HCT) is limited by graft-versus-host disease (GVHD). A sequence dimorphism in exon one of HLA-B gives rise to leader peptides containing methionine (M) or threonine (T) which differentially influence NK and T-cell alloresponses...

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Published in:Lancet Haematol
Main Authors: Petersdorf, Effie W., Carrington, Mary, O’hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J. Alejandro, Maiers, Martin J., Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen R., Villard, Jean, Stevenson, Phil
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948919/
https://ncbi.nlm.nih.gov/pubmed/31669248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2352-3026(19)30208-X
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