Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice

Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation and cell–extracellular matrix adhesion and migration. Here, we show that deleting Pinch1 in osteocytes and mature osteoblasts using the 10-kb mouse Dmp1-Cre and Pinch2 globally (double KO; dKO) results in severe osteope...

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Publicado en:JCI Insight
Autores principales: Wang, Yishu, Yan, Qinnan, Zhao, Yiran, Liu, Xin, Lin, Simin, Zhang, Peijun, Ma, Liting, Lai, Yumei, Bai, Xiaochun, Liu, Chuanju, Wu, Chuanyue, Feng, Jian Q., Chen, Di, Cao, Huiling, Xiao, Guozhi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948870/
https://ncbi.nlm.nih.gov/pubmed/31723057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131692
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