Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice

Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation and cell–extracellular matrix adhesion and migration. Here, we show that deleting Pinch1 in osteocytes and mature osteoblasts using the 10-kb mouse Dmp1-Cre and Pinch2 globally (double KO; dKO) results in severe osteope...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Wang, Yishu, Yan, Qinnan, Zhao, Yiran, Liu, Xin, Lin, Simin, Zhang, Peijun, Ma, Liting, Lai, Yumei, Bai, Xiaochun, Liu, Chuanju, Wu, Chuanyue, Feng, Jian Q., Chen, Di, Cao, Huiling, Xiao, Guozhi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948870/
https://ncbi.nlm.nih.gov/pubmed/31723057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131692
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