Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice

Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation and cell–extracellular matrix adhesion and migration. Here, we show that deleting Pinch1 in osteocytes and mature osteoblasts using the 10-kb mouse Dmp1-Cre and Pinch2 globally (double KO; dKO) results in severe osteope...

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Vydáno v:JCI Insight
Hlavní autoři: Wang, Yishu, Yan, Qinnan, Zhao, Yiran, Liu, Xin, Lin, Simin, Zhang, Peijun, Ma, Liting, Lai, Yumei, Bai, Xiaochun, Liu, Chuanju, Wu, Chuanyue, Feng, Jian Q., Chen, Di, Cao, Huiling, Xiao, Guozhi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948870/
https://ncbi.nlm.nih.gov/pubmed/31723057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131692
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