Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

β-Cell dysfunction and reduction in β-cell mass are hallmark events of diabetes mellitus. Here we show that β-cells express abundant Kindlin-2 and deleting its expression causes severe diabetes-like phenotypes without markedly causing peripheral insulin resistance. Kindlin-2, through its C-terminal...

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Publié dans:Nat Commun
Auteurs principaux: Zhu, Ke, Lai, Yumei, Cao, Huiling, Bai, Xiaochun, Liu, Chuanju, Yan, Qinnan, Ma, Liting, Chen, Di, Kanaporis, Giedrius, Wang, Junqi, Li, Luyuan, Cheng, Tao, Wang, Yong, Wu, Chuanyue, Xiao, Guozhi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981167/
https://ncbi.nlm.nih.gov/pubmed/31980627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14186-y
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