Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

β-Cell dysfunction and reduction in β-cell mass are hallmark events of diabetes mellitus. Here we show that β-cells express abundant Kindlin-2 and deleting its expression causes severe diabetes-like phenotypes without markedly causing peripheral insulin resistance. Kindlin-2, through its C-terminal...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Autores principales: Zhu, Ke, Lai, Yumei, Cao, Huiling, Bai, Xiaochun, Liu, Chuanju, Yan, Qinnan, Ma, Liting, Chen, Di, Kanaporis, Giedrius, Wang, Junqi, Li, Luyuan, Cheng, Tao, Wang, Yong, Wu, Chuanyue, Xiao, Guozhi
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981167/
https://ncbi.nlm.nih.gov/pubmed/31980627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14186-y
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares