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Hemagglutinin head-specific responses dominate over stem-specific responses following prime boost with mismatched vaccines

Broadly neutralizing Abs targeting the HA stem can provide broad protection against different influenza subtypes, raising the question of how best to elicit such Abs. We have previously demonstrated that vaccination with pandemic live-attenuated influenza vaccine (pLAIV) establishes immune memory fo...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jegaskanda, Sinthujan, Andrews, Sarah F., Wheatley, Adam K., Yewdell, Jonathan W., McDermott, Adrian B., Subbarao, Kanta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948858/
https://ncbi.nlm.nih.gov/pubmed/31723058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129035
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