Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1

Accumulating evidence suggests long non-coding RNAs (lncRNAs) play crucial roles in the pathogenesis of rheumatoid arthritis (RA). Here, we aimed to define the role of HOXA transcript at the distal tip (HOTTIP) in RA pathogenesis in relation to SFRP1 methylation and Wnt signaling pathway. HOTTIP was...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Hu, Xumin, Tang, Jianhua, Hu, Xuyun, Bao, Peng, Deng, Weixi, Wu, Jionglin, Liang, Yuwei, Chen, Zhipeng, Gao, Liangbin, Tang, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948255/
https://ncbi.nlm.nih.gov/pubmed/31902746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.11.015
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