Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1

Accumulating evidence suggests long non-coding RNAs (lncRNAs) play crucial roles in the pathogenesis of rheumatoid arthritis (RA). Here, we aimed to define the role of HOXA transcript at the distal tip (HOTTIP) in RA pathogenesis in relation to SFRP1 methylation and Wnt signaling pathway. HOTTIP was...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Hu, Xumin, Tang, Jianhua, Hu, Xuyun, Bao, Peng, Deng, Weixi, Wu, Jionglin, Liang, Yuwei, Chen, Zhipeng, Gao, Liangbin, Tang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948255/
https://ncbi.nlm.nih.gov/pubmed/31902746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.11.015
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