Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression and autophagy

Gartanin, a 4-prenylated xanthone, has been identified from the purple mangosteen fruit as a potent growth inhibitor of various cancer cell lines, including prostate cancer. However, much of Gartanin’s anti-cancer mechanism remains unknown. We have discovered that Gartanin docked onto the regulatory...

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Bibliografiska uppgifter
I publikationen:Mol Carcinog
Huvudupphovsmän: Pham, Victor, Rendon, Raymond, Le, Vinh X, Tippin, Matthew, Fu, Dong-Jun, Le, Thanh H, Miller, Marvin, Agredano, Ericka, Cedano, Jose, Zi, Xiaolin
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946862/
https://ncbi.nlm.nih.gov/pubmed/31782573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.23140
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