Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model

S phase kinase-associated protein 2 (Skp2) has been shown to be required for spontaneous tumor development that occurs in the retinoblastoma protein (pRb) deficient mice. Here we have demonstrated that flavokawain A (FKA), a novel chalcone from the kava plant, selectively inhibited the growth of pRb...

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Pubblicato in:Oncotarget
Autori principali: Li, Xuesen, Yokoyama, Noriko N., Zhang, Saiyang, Ding, Lina, Liu, Hong-min, Lilly, Michael B., Mercola, Dan, Zi, Xiaolin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747190/
https://ncbi.nlm.nih.gov/pubmed/26497688
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