Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

BACKGROUND: Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets of FKB in prostate cancer cells remain unknown. METHODS: An in vitro NEDD8 Initi...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Li, Xuesen, Pham, Victor, Tippin, Matthew, Fu, Dongjun, Rendon, Raymond, Song, Liankun, Uchio, Edward, Hoang, Bang H., Zi, Xiaolin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423783/
https://ncbi.nlm.nih.gov/pubmed/30885218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0338-2
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