A novel small molecule targets androgen receptor and its splice variants in castration-resistant prostate cancer

Reactivation of AR appears to be the major mechanism driving the resistance of CRPC to second generation antiandrogens and involves AR overexpression, AR mutation, and/or expression of AR splice variants lacking LBD. There is a need for novel small molecules targeting AR, particularly those also tar...

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Publicado no:Mol Cancer Ther
Main Authors: Yang, Zhenyu, Wang, Dan, Johnson, James K., Pascal, Laura E., Takubo, Keita, Avula, Raghunandan, Chakka, Anish Bhaswanth, Zhou, Jianhua, Chen, Wei, Zhong, Mingming, Song, Qiong, Ding, Hui, Wu, Zeyu, Chandran, Uma R., Maskrey, Taber S., Nelson, Joel B., Wipf, Peter, Wang, Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946849/
https://ncbi.nlm.nih.gov/pubmed/31554654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0489
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