A novel androgen receptor antagonist JJ-450 inhibits enzalutamide-resistant mutant AR(F876L) nuclear import and function

BACKGROUND: Castration-resistant prostate cancer can develop resistance to enzalutamide because of androgen receptor (AR) point mutations, AR overexpression, constitutively active AR splice variants, and/or elevated intratumoral androgen synthesis. The point mutation AR(F876L) was reported to be sti...

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Detalhes bibliográficos
Publicado no:Prostate
Main Authors: Wu, Zeyu, Wang, Ke, Yang, Zhenyu, Pascal, Laura E., Nelson, Joel B., Takubo, Keita, Wipf, Peter, Wang, Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7421602/
https://ncbi.nlm.nih.gov/pubmed/31868960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23945
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