Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

[Image: see text] After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure–activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-based luciferase assay. A novel...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Johnson, James K., Skoda, Erin M., Zhou, Jianhua, Parrinello, Erica, Wang, Dan, O’Malley, Katherine, Eyer, Benjamin R., Kazancioglu, Mustafa, Eisermann, Kurtis, Johnston, Paul A., Nelson, Joel B., Wang, Zhou, Wipf, Peter
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2016
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983742/
https://ncbi.nlm.nih.gov/pubmed/27563404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00186
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