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Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer
[Image: see text] After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure–activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-based luciferase assay. A novel...
שמור ב:
| הוצא לאור ב: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2016
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4983742/ https://ncbi.nlm.nih.gov/pubmed/27563404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00186 |
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