Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

[Image: see text] After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure–activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-based luciferase assay. A novel...

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Publicat a:ACS Med Chem Lett
Autors principals: Johnson, James K., Skoda, Erin M., Zhou, Jianhua, Parrinello, Erica, Wang, Dan, O’Malley, Katherine, Eyer, Benjamin R., Kazancioglu, Mustafa, Eisermann, Kurtis, Johnston, Paul A., Nelson, Joel B., Wang, Zhou, Wipf, Peter
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983742/
https://ncbi.nlm.nih.gov/pubmed/27563404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00186
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