Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

[Image: see text] After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure–activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-based luciferase assay. A novel...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Johnson, James K., Skoda, Erin M., Zhou, Jianhua, Parrinello, Erica, Wang, Dan, O’Malley, Katherine, Eyer, Benjamin R., Kazancioglu, Mustafa, Eisermann, Kurtis, Johnston, Paul A., Nelson, Joel B., Wang, Zhou, Wipf, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983742/
https://ncbi.nlm.nih.gov/pubmed/27563404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00186
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