Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

[Image: see text] After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure–activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-based luciferase assay. A novel...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:ACS Med Chem Lett
Main Authors: Johnson, James K., Skoda, Erin M., Zhou, Jianhua, Parrinello, Erica, Wang, Dan, O’Malley, Katherine, Eyer, Benjamin R., Kazancioglu, Mustafa, Eisermann, Kurtis, Johnston, Paul A., Nelson, Joel B., Wang, Zhou, Wipf, Peter
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2016
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983742/
https://ncbi.nlm.nih.gov/pubmed/27563404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00186
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