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Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response

Mechanisms that control aging are important yet poorly defined. To discover longevity control genes, we performed a forward genetic screen for delayed reproductive aging in C. elegans. Here we show that am117 is a nonsense mutation in the phm-2 gene, which encodes a protein homologous to human scaff...

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Publicado en:Dev Cell
Autores principales: Kumar, Sandeep, Egan, Brian M., Kocsisova, Zuzana, Schneider, Daniel L., Murphy, John T., Diwan, Abhinav, Kornfeld, Kerry
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946027/
https://ncbi.nlm.nih.gov/pubmed/30965033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.03.010
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