Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response

Mechanisms that control aging are important yet poorly defined. To discover longevity control genes, we performed a forward genetic screen for delayed reproductive aging in C. elegans. Here we show that am117 is a nonsense mutation in the phm-2 gene, which encodes a protein homologous to human scaff...

Full description

Saved in:
Bibliographic Details
Published in:Dev Cell
Main Authors: Kumar, Sandeep, Egan, Brian M., Kocsisova, Zuzana, Schneider, Daniel L., Murphy, John T., Diwan, Abhinav, Kornfeld, Kerry
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946027/
https://ncbi.nlm.nih.gov/pubmed/30965033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.03.010
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items