Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

Although obesity with associated inflammation is now recognized as a risk factor for breast cancer and distant metastases, the functional basis for these connections remain poorly understood. Here, we show that in breast cancer patients and in animal breast cancer models, obesity is a sufficient cau...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Nagahashi, Masayuki, Yamada, Akimitsu, Katsuta, Eriko, Aoyagi, Tomoyoshi, Huang, Wei-Ching, Terracina, Krista P., Hait, Nitai C., Allegood, Jeremy C., Tsuchida, Junko, Yuza, Kizuki, Nakajima, Masato, Abe, Manabu, Sakimura, Kenji, Milstien, Sheldon, Wakai, Toshifumi, Spiegel, Sarah, Takabe, Kazuaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945803/
https://ncbi.nlm.nih.gov/pubmed/29351902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1423
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