Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

Although obesity with associated inflammation is now recognized as a risk factor for breast cancer and distant metastases, the functional basis for these connections remain poorly understood. Here, we show that in breast cancer patients and in animal breast cancer models, obesity is a sufficient cau...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Nagahashi, Masayuki, Yamada, Akimitsu, Katsuta, Eriko, Aoyagi, Tomoyoshi, Huang, Wei-Ching, Terracina, Krista P., Hait, Nitai C., Allegood, Jeremy C., Tsuchida, Junko, Yuza, Kizuki, Nakajima, Masato, Abe, Manabu, Sakimura, Kenji, Milstien, Sheldon, Wakai, Toshifumi, Spiegel, Sarah, Takabe, Kazuaki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945803/
https://ncbi.nlm.nih.gov/pubmed/29351902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1423
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