A Long Acting Nanoformulated Lamivudine ProTide

A long acting (LA) hydrophobic and lipophilic lamivudine (3TC) was created as a phosphoramidate pronucleotide (designated M23TC). M23TC improved intracellular delivery of active triphosphate metabolites and enhanced antiretroviral and pharmacokinetic (PK) profiles over the native drug. A single trea...

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Опубликовано в: :Biomaterials
Главные авторы: Smith, Nathan, Bade, Aditya N., Soni, Dhruvkumar, Gautam, Nagsen, Alnouti, Yazen, Herskovitz, Jonathan, Ibrahim, Ibrahim M., Wojtkiewicz, Melinda S., Dyavar Shetty, Bhagya Laxmi, McMillan, JoEllyn, Gendelman, Howard E., Edagwa, Benson
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945491/
https://ncbi.nlm.nih.gov/pubmed/31525692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2019.119476
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