Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

BACKGROUND: Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critical in driving spine loss and disease pathogenesis. Complement signaling is init...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Datta, Dibyadeep, Leslie, Shannon N., Morozov, Yury M., Duque, Alvaro, Rakic, Pasko, van Dyck, Christopher H., Nairn, Angus C., Arnsten, Amy F. T.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945481/
https://ncbi.nlm.nih.gov/pubmed/31906973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1683-1
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